Neuropathology of two Brazilian autopsied cases of tropical spastic paraparesis / HTLV-I associated myelopathy (TSP/HAM) of long evolution.

Autor: Castro-Costa CM; Laboratory of Experimental Neurology, Department of Physiology and Pharmacology, Federal University of Ceará, Fortaleza, Ceará, Brazil. pst016@sec.secrel.com.br, Dom R, Carton H, Goubau P, Santos Tde J, Ferreira MV, Silva Neto FU
Jazyk: angličtina
Zdroj: Arquivos de neuro-psiquiatria [Arq Neuropsiquiatr] 2002 Sep; Vol. 60 (3-A), pp. 531-6.
DOI: 10.1590/s0004-282x2002000400003
Abstrakt: We report on a neuropathological analysis of two cases of TSP/HAM originating from Brazil. These two cases had, respectively, an evolution of 13 and 40 years. The main neuropathological findings consisted of spinal cord atrophy, mainly the lower thoracic cord, diffuse degeneration of the white and grey matter, rare foci of mononuclear and perivascular cuffs, and hyaline hardening of arteriolae. The supraspinal structures were normal, excepting for a slight gliosis in the cerebellum. An analysis on the long evolutive cases as described in the literature is outlined in this study.
Databáze: MEDLINE