| Autor: |
Banwell MG; Research School of Chemistry, Institute of Advanced Studies, The Australian National University, Canberra, ACT 0200, Australia. mgb@rsc.anu.edu.au, Crasto CF, Easton CJ, Karoli T, March DR, Nairn MR, O'Hanlon PJ, Oldham MD, Willis AC, Yue W |
| Jazyk: |
angličtina |
| Zdroj: |
Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2001 Nov 07 (21), pp. 2210-1. |
| Abstrakt: |
The ketone (+/-)-5, which embodies the bicyclic core associated with the title tRNA synthetase inhibitors 1 and 2, has been prepared via a three-component coupling reaction involving 2-(hydroxymethyl)cyclopent-2-enone (15), methylamine (6) and propiolamide (10); straightforward elaboration of the readily derived acetates (-)-21 and (+)-21 has provided the biologically active analogues 23 and 24, respectively, of the title compounds. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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