Polyploidization and centrosome hyperamplification in inflammatory bronchi.

Autor: Lothschütz D; Department of Trauma-, Hand- and Reconstructive Surgery, Saarland University, Homburg, Germany., Jennewein M, Pahl S, Lausberg HF, Eichler A, Mutschler W, Hanselmann RG, Oberringer M
Jazyk: angličtina
Zdroj: Inflammation research : official journal of the European Histamine Research Society ... [et al.] [Inflamm Res] 2002 Aug; Vol. 51 (8), pp. 416-22.
DOI: 10.1007/pl00000323
Abstrakt: Objective and Design: Inflammatory and tumorous bronchi were screened in order to obtain new tumor relevant cytogenetic parameters.
Material or Subjects: Bronchial cells of 32 patients were cultivated by standard cell culture procedures.
Methods: Tetraploidy and aneuploidy was determined by enumeration of chromosome 7 and 8 versus the number of centrosomes. The resulting data were correlated with histopathological data.
Results: Tetra- and aneuploidy of epithelial cells were detectable in 76% of tumor cell cultures, 75% of high grade inflammatory tissues and 40% of non- and low grade-inflammatory tissues. Additionally, we observed centrosome hyper-amplification and multipolar mitoses not only in the tumor but also in the early stages of inflammation.
Conclusion: Inflammatory bronchi already show tumor-specific features and may consequently represent the preliminary genetic stage of cancer development in bronchi.
Databáze: MEDLINE
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