| Autor: |
Løvig T; Institute of Forensic Medicine, The National Hospital, University of Oslo, 0027 Oslo, Norway. tone.loving@labmed.uio.no, Andersen SN, Thorstensen L, Diep CB, Meling GI, Lothe RA, Rognum TO |
| Jazyk: |
angličtina |
| Zdroj: |
British journal of cancer [Br J Cancer] 2002 Sep 23; Vol. 87 (7), pp. 756-62. |
| DOI: |
10.1038/sj.bjc.6600507 |
| Abstrakt: |
Progression of colorectal cancer may follow either of two main genetic routes: the chromosome- or microsatellite-instability pathways. Association between the patients' prognosis and microsatellite instability has been questioned. Improved survival has previously been found in patients with expression of HLA-DR antigens on their tumour cells. In this study, the expression of HLA-DR antigen was investigated by immunohistochemistry in 357 large bowel carcinomas stratified by microsatellite instability status. Sixteen per cent of the tumours showed strong HLA-DR expression and 35% had weak DR expression. We confirmed that patients with strong positive HLA-DR staining had improved survival (P<0.001) compared to patients with no HLA-DR expression. Strong epithelial HLA-DR staining was significantly associated with high level of microsatellite instability (P<0.001). In the subgroup of tumours with characteristics typical of the chromosomal instability phenotype, i.e. in microsatellite-stable tumours, the patients positive for the HLA-DR determinants showed better survival than those without HLA-DR expression. The protective effect of HLA-DR expression on survival was confirmed by multivariate analysis, both in the whole patient group and in the microsatellite-stable/microsatellite instability-low group. This might be explained by enhanced T-cell mediated anti-tumour immune responses against tumour cells in the HLA-DR positive tumours. The finding of better patient survival in the subgroup of strong HLA-DR positive microsatellite-stable tumours may have clinical implications for these patients. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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