| Autor: |
Karpova OA; Molecular Genetics and Immunology Department, Research Center for Toxicological and Hygienic Control of Biopreparations, ul. Lenina 102A, Serpukhov, Moscow Oblast, 142253 Russia., Mikhina LV, Denisov AA, Kuz'mich MK |
| Jazyk: |
ruština |
| Zdroj: |
Eksperimental'naia i klinicheskaia farmakologiia [Eksp Klin Farmakol] 2002 May-Jun; Vol. 65 (3), pp. 54-6. |
| Abstrakt: |
The antimutagen effect of the drug hypoxen, representing poly(2,5-dihydroxyphenylene)-4-thiosulfonic acid sodium salt, was studied by chromosome aberration assay in the bone marrow cells of C57BL/6 mice. Hypoxen (20 mg/kg, i.p.) administered simultaneously with dioxidine (300 mg/kg, i.p.) reduced genotoxicity of the latter compound by 35% over a time period of 24 h. Preliminary five-day administration of hypoxen (70 mg/kg, p.o.) did not decrease the dioxidine damage. The genoprotector activity of hypoxen upon interaperitoneal injection is more pronounced as compared to that of the reference drug sladex (aspartam). |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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