| Autor: |
Marusova IB; Valdman Institute of Pharmacology, Pavlov State Medical University, ul. L. Tolstogo 6/8, St. Petersburg, 197022 Russia., Vlasov TD, Marusov IV, Panchenko AV |
| Jazyk: |
ruština |
| Zdroj: |
Eksperimental'naia i klinicheskaia farmakologiia [Eksp Klin Farmakol] 2002 May-Jun; Vol. 65 (3), pp. 16-8. |
| Abstrakt: |
Montelukast sodium, a specific leukotriene receptor (CysLT1) blocker administered orally in a dose of 40 mg/kg prevented the stomach mucosa in rats from acute erosive gastritis model induced by acetylsalicylic acid (150 mg/kg, p.o.) in male albino Wistar rats. The potential role of a "5-lipooxygenase shunting" of the arachidonic acid metabolism in the gastrointestinal toxicity of non-selective cyclooxygenase inhibitors is discussed. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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