| Autor: |
Diamond J; Department of Otolaryngology-Head and Neck Surgery, University of Iowa Hospital and Clinics, 200 Hawkins Dr., Iowa City, IA 52242, USA., Skaggs J, Manaligod JM |
| Jazyk: |
angličtina |
| Zdroj: |
Ear, nose, & throat journal [Ear Nose Throat J] 2002 Aug; Vol. 81 (8), pp. 531-3. |
| Abstrakt: |
We conducted a study of lipid peroxidation as a marker of age-related free-radical damage in the human larynx--the first study of its kind. A colorimetric assay for malondialdehyde (MDA) and 4-hydroxy-2-nonenal (4-HNE) was performed on extracts taken from thyroarytenoid muscle harvested from fresh cadaveric laryngeal specimens. Levels of MDA and 4-HNE were measured by spectrophotometry. Correlation studies were performed by linear regression analysis. We found that MDA levels in human thyroarytenoid muscle appeared to increase with age while 4-HNE levels showed a slight decrease with age. Our findings are consistent with those of previous studies of other organ systems and indicate that there is a need for further study of free-radical damage and the effects of aging on the human larynx and on voice production. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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