| Autor: |
Roth GS; Laboratory of Neurosciences, National Institute on Aging, Baltimore, Maryland 21224, USA., Handy AM, Mattison JA, Tilmont EM, Ingram DK, Lane MA |
| Jazyk: |
angličtina |
| Zdroj: |
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme [Horm Metab Res] 2002 Jul; Vol. 34 (7), pp. 378-82. |
| DOI: |
10.1055/s-2002-33469 |
| Abstrakt: |
Plasma levels of thyroid hormones - triiodothyronine (T 3 ), thyroxin (T 4 ), and thyroid-stimulating hormone (TSH) were measured in male and female rhesus monkeys (Macaca mulatta) fed either ad libitum or a 30 % calorie-restricted (CR) diet (males for 11 years; females for 6 years). The same hormones were measured in another group of young male rhesus monkeys during adaptation to the 30 % CR regimen. Both long- and shorter-term CR diet lowered total T 3 in plasma of the monkeys. The effect appeared to be greater in younger monkeys than in older counterparts. No effects of CR diet were detected for either free or total T 4, although unlike T 3, levels of this hormone decreased with age. TSH levels also decreased with age, and were increased by long-term CR diet in older monkeys only. No consistent effects of shorter-term CR diet were observed for TSH. In the light of the effects of the thyroid axis on overall metabolism, these results suggest a possible mechanism by which CR diets may elicit their well-known beneficial 'anti-aging' effects in mammals. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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