| Autor: |
Roger-Liautaud F; Institut Jean-Godinot, Secteur Prevention, Reims, France., Gimonet D, Merol JC, Prevost A, Coninx P |
| Jazyk: |
angličtina |
| Zdroj: |
Anticancer research [Anticancer Res] 2002 Jul-Aug; Vol. 22 (4), pp. 2419-22. |
| Abstrakt: |
The Bleomycin (BLM)-induced apoptosis in peripheral blood mononuclear cells (PBMC), from patients with advanced squamous cell carcinoma of the head and neck (SCCHN), cultured in vitro with PHA, was tested as a predictive indicator of the survival time. The rates of the PBMC BLM-induced apoptosis and of the cycling-PBMCs, measured respectively after Giemsa- and Feulgen-staining were determined in 25 patients before induction chemotherapy. By using the Cox model, the survival probability was significantly and independently increased for a high percentage of PBMC BLM-induced apoptosis and a high rate of cycling PBMCs. (Chi-2(2): 10; p=0.007). Six patients, in whom both PBMC variables were simultaneouly greater than the median values, showed a median survival time as long as 60 months versus 10 months for the other 19. Conclusively, the PBMC susceptibility to BLM-induced apoptosis as well as the PBMC capability for cycling may be regarded as independent pretherapeutic prognosis factors for patients with advanced SCCHN. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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