Acute fatty liver of pregnancy and acetaminophen toxicity leading to liver failure and postpartum liver transplantation. A case report.

Autor:	Gill EJ; Departments of Obstetrics and Gynecology and of Pathology, Medical College of Virginia, Virginia Commonwealth University, Richmond, USA. egill@hsc.vcu.edu, Contos MJ, Peng TC
Jazyk:	angličtina
Zdroj:	The Journal of reproductive medicine [J Reprod Med] 2002 Jul; Vol. 47 (7), pp. 584-6.
Abstrakt:	Background: Acute fatty liver of pregnancy is a rare entity. A MEDLINE English-language search from 1966 to the present revealed no reports of acetaminophen toxicity and acute fatty liver in pregnancy. Case: An 18-year-old, African American woman, gravida 1, presented at 33 weeks' gestation with signs and symptoms consistent with acute fatty liver of pregnancy and fetal death. Markedly elevated transaminases prompted a search for other etiologies, and acetaminophen toxicity was diagnosed. Liver biopsy revealed acute fatty liver of pregnancy and toxin-induced injury consistent with acetaminophen use. The patient's condition deteriorated, resulting in fulminant hepatic failure and requiring postpartum orthotopic liver transplantation. Conclusion: The combination of acute fatty liver of pregnancy and acetaminophen toxicity resulted in acute liver failure. Attention to clinical and biochemical parameters can lead to diagnosis and management.
Databáze:	MEDLINE
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