| Autor: |
Duffy KJ, Price AT, Delorme E, Dillon SB, Duquenne C, Erickson-Miller C, Giampa L, Huang Y, Keenan RM, Lamb P, Liu N, Miller SG, Rosen J, Shaw AN, Smith H, Wiggall KJ, Zhang L, Luengo JI |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of medicinal chemistry [J Med Chem] 2002 Aug 15; Vol. 45 (17), pp. 3576-8. |
| DOI: |
10.1021/jm0255365 |
| Abstrakt: |
The invention of a new class of naphtho[1,2-d]imidazole thrombopoietin mimics based on a pharmacophore hypothesis for small-molecule thrombopoietic agonists is discussed. Parallel array synthesis and purification techniques allowed for the rapid exploration of structure-activity relationships within this class and for the improvement in TPO mimetic potencies and efficacies. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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