| Autor: |
Miguel JC; Museo de Anatomía Normal, Facultad de Ciencias Médicas, Rosario, Argentina., Erazo A, Beduino F, Picena JC, Luciano MI, Pizzutti G, Tarrés MC, Montenegro S, Martínez SM |
| Jazyk: |
Spanish; Castilian |
| Zdroj: |
Biomedica : revista del Instituto Nacional de Salud [Biomedica] 2002 Jun; Vol. 22 (2), pp. 110-5. |
| Abstrakt: |
Bronchiectasis occurred naturally in 12-month-old spontaneously diabetic eSS male rats. The lungs of 3 and 6-month-old eSS rats were compared in eumetabolic eSS rats from three inbred lines consisting of inbred spontaneously diabetic eSS derived from IIM strain; these were compared with eumetabolic, outbred Wistar rats, paired by sex and age. Acrylic casts of bronchial tree were obtained after injection of a plastic substance. The casts were pruned to focus on the first four bronchial branchings. Diameter and volume of the conductive bronchial tree were determined using a binocular magnifier. Histological sections were obtained. All lines showed multiple bronchiectasis, mostly fusiform, bronchial dilatation and inflammatory response with lymphocytic infiltrates. These symptoms were much more severe in 180-day-old eSS males. Bacteria were isolated from the lungs in 70% of cases (n = 32), except in eSS rats. Pseudomonas spp. (38%) and Gram-positive cocci as coagulase-negative Staphylococcus spp. (20%) were detected. Neither pathogenic bacteria nor saprophyte fungi were found. Although all lines were affected, diabetes in eSS appears to be an aggravating factor. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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