Experimental substantiation of the possibility of developing selenium- and iodine-containing pharmaceuticals based on blue-green algae Spirulina platensis.

Autor: Mosulishvili LM; EL Andronikashvili Institute of Physics, Georgian Academy of Sciences, Tamarashvili str 6, 380077, Tbilisi, Georgia., Kirkesali EI, Belokobylsky AI, Khizanishvili AI, Frontasyeva MV, Pavlov SS, Gundorina SF
Jazyk: angličtina
Zdroj: Journal of pharmaceutical and biomedical analysis [J Pharm Biomed Anal] 2002 Aug 22; Vol. 30 (1), pp. 87-97.
DOI: 10.1016/s0731-7085(02)00199-1
Abstrakt: The great potential of using blue-green algae Spirulina platensis as a matrix for the production of selenium- and iodine-containing pharmaceuticals is shown experimentally. The background levels of 31 major, minor and trace elements (Na, Mg, Al, Cl, K, Ca, Sc, V, Cr, Mn, Fe, Co, Ni (using (n,p) reaction), As, Br, Zn, Rb, Mo, Ag, Sb, I, Ba, Sm, Tb, Tm, Hf, Ta, W, Au, Hg, Th) in S. platensis biomass were determined by means of epithermal neutron activation analysis. The dependence of selenium and iodine accumulation in spirulina biomass on a nutrient medium loading of the above elements was characterized. To demonstrate the possibilities of determining toxic element intake by spirulina biomass, mercury was selected. The technological parameters for production of iodinated treatment-and-prophylactic pills are developed.
Databáze: MEDLINE