[Experimental and clinical rationale for complex treatment of mental disorders in clean-up workers of the Chernobyl nuclear plant accident].

Autor: Neznamov GG; Laboratory of Clinical Psychopharmacology, Laboratory of Psychopharmacology, Russian Academy of Medical Sciences, Baltiiskaya ul. 8, Moscow, 125315 Russia., Koshelev VV, Voronina TA, Trofimov SS
Jazyk: ruština
Zdroj: Eksperimental'naia i klinicheskaia farmakologiia [Eksp Klin Farmakol] 2002 Mar-Apr; Vol. 65 (2), pp. 12-6.
Abstrakt: Piracetam is an effective drug for the treatment of asthenic and intellectual-mnestic disorders. However, this drug induces superfluous stimulation which reduces the therapeutic effect in rescuers after Chernobyl nuclear power disaster. The results of experimental and clinical investigations show that the administration of gidazepam--an atypical benzodiazepine tranquilizer--in combination with piracetam produces correction of the undesired stimulant action of the latter drug, while potentiating the nootropic (antiamnesic) and anxiolytic effects. This drug interaction led to an improvement in the therapy.
Databáze: MEDLINE
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