| Autor: |
van Bilsen JH; Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, The Netherlands., Wagenaar-Hilbers JP, van der Cammen MJ, van Dijk ME, van Eden W, Wauben MH |
| Jazyk: |
angličtina |
| Zdroj: |
Arthritis research [Arthritis Res] 2002; Vol. 4 (4), pp. R2. Date of Electronic Publication: 2002 May 07. |
| DOI: |
10.1186/ar421 |
| Abstrakt: |
We have recently found that matrix metalloproteinases (MMPs) are targets for T-cell and B-cell reactivity in experimental arthritis. In the present article, we investigate whether modulation of MMP-specific T-cell responses could influence the course of adjuvant arthritis (AA). Lewis rats were treated nasally with MMP peptides prior to or after AA induction. Administration of the MMP-10 or the MMP-16 peptide prior to AA induction reduced the arthritic symptoms. In contrast, administration of the MMP-10 peptide after AA induction aggravated the arthritic symptoms. The present study shows the possible usefulness of MMP peptides for immunotherapy. However, a clear understanding of proper timing of peptide administration is crucial for the development of such therapies. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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