| Autor: |
Theoclitou ME; Bristol-Myers Squibb, Pharma Research Laboratories, 4570 Executive Drive, San Diego, California 92121, USA. Maria-Elena.Thouclitou@dupontpharma, Delaet NG, Robinson LA |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of combinatorial chemistry [J Comb Chem] 2002 Jul-Aug; Vol. 4 (4), pp. 315-9. |
| DOI: |
10.1021/cc010094o |
| Abstrakt: |
Combinatorial libraries of substituted 3-thio-1,2,4-triazoles and 2-thioimidazoles were synthesized in good yield by alkylation of the products via the reaction of isothiocyanates and carboxylic acid hydrazides or beta-aminoketones, respectively. A total of 275 3-thio-1,2,4-triazoles and 283 2-thioimidazoles were synthesized out of the attempted 288 in each case. Most the yields were between 45% and 98%, and all the compounds synthesized were purified to >85% purity. Variations in yields revealed no definitive trends and were mainly attributed to bulky alkylating agents used and the plate well location of the reaction mixtures. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
|
