Increased expression and redistribution of the antiapoptotic molecule Bcl-xL in Parkinson's disease.

Autor: Hartmann A; INSERM U 289, Hôpital de la Salpêtrière, 75013 Paris, France., Mouatt-Prigent A, Vila M, Abbas N, Perier C, Faucheux BA, Vyas S, Hirsch EC
Jazyk: angličtina
Zdroj: Neurobiology of disease [Neurobiol Dis] 2002 Jun; Vol. 10 (1), pp. 28-32.
DOI: 10.1006/nbdi.2002.0494
Abstrakt: In the present study, we tried to clarify the potentially protective role of Bcl-x(L), an anti-apoptotic member of the Bcl-2 family of proteins, in Parkinson's disease (PD). Using in situ hybridization on human postmortem mesencephalon sections, we show that in PD patients Bcl-x(L) mRNA expression per dopaminergic neuron was almost double that of controls. We also show that, ultrastructurally, this effect may be mediated by a redistribution of Bcl-x(L) from the cytosol to the outer mitochondrial membrane.
(2002 Elsevier Science (USA).)
Databáze: MEDLINE
Externí odkaz: