| Autor: |
Khripach VA; Institute of Bioorganic Chemistry, National Academy of Sciences of Belarus, ul. Kuprevicha 5/2, Minsk, 220141 Belarus. khripach@iboch.bas-net.by, Zhabinskiĭ VN, Konstantinova OV, Khripach NB, Antonchik AP |
| Jazyk: |
ruština |
| Zdroj: |
Bioorganicheskaia khimiia [Bioorg Khim] 2002 May-Jun; Vol. 28 (3), pp. 284-8. |
| DOI: |
10.1023/a:1015720707433 |
| Abstrakt: |
The syntheses of (24S)-24,25-epoxycholesterol, (24S)-hydroxycholesterol, and 24-ketocholesterol are described. The compounds belong to oxysterols, which can be considered to be the modulators of cholesterol metabolism. The asymmetric hydroxylation of desmosterol acetate according to Sharpless was used as the key reaction in the stereoselective introduction of functionality in position 24. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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