| Autor: |
Scheen AJ; Service de Diabétologie, Nutrition et Maladies métaboliques, Département de Médecine, CHU Sart Tilman., Letiexhe MR, Geronooz I, Paquot N, Jandrain B |
| Jazyk: |
francouzština |
| Zdroj: |
Revue medicale de Liege [Rev Med Liege] 2002 Apr; Vol. 57 (4), pp. 196-201. |
| Abstrakt: |
Besides dietary approaches, various pharmacological means have been recently developed in order to better control postprandial hyperglycaemia. This objective may be obtained: 1) by slowing down the intestinal absorption of carbohydrates; 2) by insuring a better insulin priming soon after the meal; and 3) by inhibiting post-prandial glucagon secretion or action. Some hormones (amylin, glucagon-like peptide-1) can slow gastric emptying while alpha-glucosidase inhibitors (acarbose, miglitol) retard intestinal digestion and resorption of complex carbohydrates. A more physiological post-meal profile of insulin may be obtained in type 2 diabetes by using new insulin secretagogues of the glinide family (repaglinide, nateglinide) with an earlier and shorter insulinotropic action or, mainly in type 1 diabetes but also in type 2 diabetes, by using short-acting insulin analogues (lispro. Asp B28) or inhated insulin the action of which is faster than that of subcutaneous insulin. Post-prandial glucagon secretion can be inhibited by amylin. GLP-1 or insulin while other glucagon antagonists are currently in development. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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