Is glucagonoma of the pancreas a curable disease?

Autor: Chu QD; Department of Surgical Oncology, Roswell Park Cancer Institute, State University of New York at Buffalo, 14263-0001, USA., Al-kasspooles MF, Smith JL, Nava HR, Douglass HO Jr, Driscoll D, Gibbs JF
Jazyk: angličtina
Zdroj: International journal of pancreatology : official journal of the International Association of Pancreatology [Int J Pancreatol] 2001; Vol. 29 (3), pp. 155-62.
DOI: 10.1385/IJGC:29:3:155
Abstrakt: Background: Glucagonomas are rare neuroendocrine tumors of the pancreas. Because of its rarity, its natural history is not well understood.
Aim: We evaluated the natural history of glucagonomas treated at a tertiary care cancer center.
Methods: A retrospective analysis of 12 patients during 1970 to 2000 was performed. Six patients (50%) had a tumor located in the head of the pancreas.
Results: Abdominal pain (83%) and weight loss (75%) were the most common symptoms. Median tumor size was 6 cm (range 0.04-10). Seven patients (58%) had liver metastases. Five patients (42%) underwent curative resection. Overall median survival was 66 mo, and 5-yr overall survival was 66%. Five-yr overall survival was 83% for patients who had resection versus 50% for the non-resected patients (p = 0.04). Patients who were disease-free had a complete resection of the primary tumor and no liver involvement.
Conclusions: Glucagonomas generally present with liver metastases at the time of diagnosis. Cure is only possible if the disease is localized and completely resected.
Databáze: MEDLINE
Externí odkaz: