| Autor: |
Mantell LL; CardioPulmonary Research Institute, Winthrop University Hospital, State University of New York at Stony Brook School of Medicine, Mineola, New York 11501, USA. lmantell@winthrop.org, Shaffer TH, Horowitz S, Foust R 3rd, Wolfson MR, Cox C, Khullar P, Zakeri Z, Lin L, Kazzaz JA, Palaia T, Scott W, Davis JM |
| Jazyk: |
angličtina |
| Zdroj: |
American journal of physiology. Lung cellular and molecular physiology [Am J Physiol Lung Cell Mol Physiol] 2002 Jul; Vol. 283 (1), pp. L31-41. |
| DOI: |
10.1152/ajplung.00037.2001 |
| Abstrakt: |
To determine whether liquid ventilation (LV) causes less cell injury and improves lung function compared with conventional gas ventilation (GV), we analyzed pulmonary physiological profiles, lung histology, and cell death in 110- and 120-day preterm lambs, which were randomized to receive either ventilation modality on FI(O(2)) = 1. LV lungs were well expanded with adequate pulmonary function, whereas GV animals exhibited marked atelectasis, poor pulmonary function, and increased mortality. Both ventilatory strategies induced marked lung cell apoptosis, but with distinct patterns of distribution. Although GV induced apoptosis of epithelium primarily in the lining and within the lumina of bronchioles, LV induced significant apoptosis much more homogeneously throughout lung parenchyma including alveoli and interstitial spaces. These studies suggest that although both forms of ventilation cause regional apoptosis, LV more effectively delivers oxygen and recruits the lung more homogeneously than GV. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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