Comparison of echocardiographic changes after short- and long-duration spaceflight.
| Autor: | Martin DS; Wyle Laboratories, Houston, Texas, USA., South DA, Wood ML, Bungo MW, Meck JV |
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| Jazyk: | angličtina |
| Zdroj: | Aviation, space, and environmental medicine [Aviat Space Environ Med] 2002 Jun; Vol. 73 (6), pp. 532-6. |
| Abstrakt: | Background: Previous echocardiographic studies of astronauts before and after short-duration (4-17 d) missions have demonstrated a decrease in resting left ventricular stroke volume, but maintained ejection fraction (EF) and cardiac output. Similar studies before and after long-duration (129-144 d) spaceflight have been rare and their overall results equivocal. Methods: Echocardiographic measurements (M-mode, 2-D, and Doppler) were obtained from short-duration (n = 13) and long-duration (n = 4) crewmembers to evaluate cardiac chamber sizes and function. Results: Compared with short-duration astronauts, long-duration crewmembers had decreases in EF (+6+/-0.02 vs. -10.5+/-0.03%, p = 0.005) and percent fractional shortening (+7+/-0.03 vs. -11+/-0.07%, p = 0.015), and an increase in left ventricular end systolic volume (-12+/-0.06 vs. +39+/-0.24%, p = 0.011). Conclusions: These data suggest a reduction in cardiac function that relates to mission duration. As the changes in BP and circulating blood volume are reported to be similar after short- and long-duration flights, the smaller EF after longer spaceflights may be due to a decrease in cardiac function rather than altered blood volume. |
| Databáze: | MEDLINE |
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