| Autor: |
Colson AE; Channing Laboratory, Brigham and Women's Hospital and Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA. acolson@challiance.org, Keller MJ, Sax PE, Pettus PT, Platt R, Choo PW |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of acquired immune deficiency syndromes (1999) [J Acquir Immune Defic Syndr] 2002 May 01; Vol. 30 (1), pp. 27-32. |
| DOI: |
10.1097/00042560-200205010-00004 |
| Abstrakt: |
To determine whether treatment with protease inhibitors (PIs) is associated with male sexual dysfunction, we conducted a retrospective, cohort study of 254 adult male PI recipients who received care from the staff-model division of a large managed care organization in New England between 1993 and 1998. After a median of 5.0 years of observation, 80 incident cases of sexual dysfunction were observed. Relative to unexposed individuals, the rate of sexual dysfunction adjusted for confounding was most elevated with use of ritonavir (hazard ratio [HR], 2.83; 95% confidence interval [CI], 1.34-5.97; p =.006) followed by indinavir (HR, 1.69; 95% CI, 0.84-3.37; p =.14), nelfinavir (HR, 1.53; 95% CI, 0.66-3.54; p =.32) and saquinavir (HR, 1.25; 95% CI, 0.53-2.96; p =.60). We conclude that PIs, especially ritonavir, appear to increase the risk of sexual dysfunction. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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