Evaluation of the clonality of multilobar bronchioloalveolar carcinoma of the lung: case report.

Autor: Nanki N; First Department of Internal Medicine, Kagawa Medical University, Kochi, Japan., Fujita J, Hojo S, Yang Y, Bandoh S, Ohara N, Miyatani K, Yamaji Y, Ohtsuki Y, Ishida T
Jazyk: angličtina
Zdroj: American journal of clinical oncology [Am J Clin Oncol] 2002 Jun; Vol. 25 (3), pp. 291-5.
DOI: 10.1097/00000421-200206000-00019
Abstrakt: A case of multilobar bronchioloalveolar carcinoma (BAC) is reported. To investigate the clonality of BAC, immunohistochemical staining as well as genetic analysis were performed. To investigate point mutations of the p53 gene, we used the polymerase chain reaction and fluorescence-based single strand conformation polymorphism analysis method. The BAC tissues of the right upper lobe, right lower lobe, and the other lobes were considered to be multiclonal. This case suggests that multilobar BAC might occur with multiclonality.
Databáze: MEDLINE