| Autor: |
Ohira S; Department of Biological Chemistry, Faculty of Science, Okayama University of Science, Japan. sohira@dbc.ous.ac.jp, Akiyama M, Kamihara K, Isoda Y, Kuboki A |
| Jazyk: |
angličtina |
| Zdroj: |
Bioscience, biotechnology, and biochemistry [Biosci Biotechnol Biochem] 2002 Apr; Vol. 66 (4), pp. 887-91. |
| DOI: |
10.1271/bbb.66.887 |
| Abstrakt: |
(1S,3R)-1-Aminocyclopentane-1,3-dicarboxylic acid (ACPD), a potent agonist of metabotropic glutamate receptors, was synthesized from L-serine. The chiral quaternary center was constructed by C-H insertion of the alkylidenecarbene, this being generated by the reaction between lithiotrimethylsilyldiazomethane and the corresponding ketone. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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