Flavanone and flavonol glycosides from the leaves of Thevetia peruviana and their HIV-1 reverse transcriptase and HIV-1 integrase inhibitory activities.

2)-[alpha-L-rhamnopyranosyl-(1-->6)]-beta-D-galactopyranoside] (peruvianoside III, 13) were isolated from the leaves of Thevetia peruviana Schum., together with nine known flavonol glycosides and two known iridoid glucosides. The structures of all compounds were determined on the basis of chemical and spectroscopic methods. Their inhibitory effects against HIV-1 reverse transcriptase and HIV-1 integrase were also investigated. -->
Substance Nomenclature: 0 (Flavonoids)
0 (Glycosides)
0 (HIV Integrase Inhibitors)
0 (Reverse Transcriptase Inhibitors)
EC 2.7.7.49 (HIV Reverse Transcriptase)
Entry Date(s): Date Created: 20020531 Date Completed: 20021129 Latest Revision: 20190706
Update Code: 20240829
DOI: 10.1248/cpb.50.630
PMID: 12036017
Autor: Tewtrakul S; Institute of Natural Medicine, Toyama Medical and Pharmaceutical University, Sugitani, Japan., Nakamura N, Hattori M, Fujiwara T, Supavita T
Jazyk: angličtina
Zdroj: Chemical & pharmaceutical bulletin [Chem Pharm Bull (Tokyo)] 2002 May; Vol. 50 (5), pp. 630-5.
DOI: 10.1248/cpb.50.630
Abstrakt: Two new flavanone glucosides, (2R)- and (2S)-5-O-beta-D-glucopyranosyl-7,4'-dihydroxy-3',5'-dimethoxyflavanone[pervianoside I (3), peruvianoside II(4)] and a new flavonol glycoside, quercetin 3-O-[beta-D-glucopyranosyl-(1-->2)-[alpha-L-rhamnopyranosyl-(1-->6)]-beta-D-galactopyranoside] (peruvianoside III, 13) were isolated from the leaves of Thevetia peruviana Schum., together with nine known flavonol glycosides and two known iridoid glucosides. The structures of all compounds were determined on the basis of chemical and spectroscopic methods. Their inhibitory effects against HIV-1 reverse transcriptase and HIV-1 integrase were also investigated.
Databáze: MEDLINE
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