| Autor: |
Fraser RD; Division of Protein Chemistry, CSIRO, Parkville, Victoria, Australia., MacRae TP |
| Jazyk: |
angličtina |
| Zdroj: |
Bioscience reports [Biosci Rep] 1983 Jun; Vol. 3 (6), pp. 517-25. |
| DOI: |
10.1007/BF01120695 |
| Abstrakt: |
Quantitative measurements of the intensity of the meridional reflections in the X-ray-diffraction pattern of alpha-keratin are shown to be consistent with a microfibril structure in which a surface lattice with an axially projected period around 200 A is subject to a periodic interruption with an axially projected period of 470 A. Taken in conjunction with recent evidence on the chemical structure of alpha-keratin and other intermediate filaments this finding enables an elaboration to be made of a model proposed earlier by RDB Fraser, TP MacRae, & E Suzuki (J. Mol. Biol. 108, 435-452, 1976) for the alpha-helical framework of the microfibril. The disposition and connectivity of the helical segments suggested here provides a straightforward explanation of a number of recent physicochemical and electron-microscopical observations on intermediate filaments and provides a starting point for the development of models for the framework of other intermediate filaments. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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