| Autor: |
Apers S; Department of Pharmaceutical Sciences, University of Antwerp, Universiteitsplein 1, B-2610 Antwerp, Belgium., Paper D, Bürgermeister J, Baronikova S, Van Dyck S, Lemière G, Vlietinck A, Pieters L |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of natural products [J Nat Prod] 2002 May; Vol. 65 (5), pp. 718-20. |
| DOI: |
10.1021/np0103968 |
| Abstrakt: |
A series of synthetic dihydrobenzofuran lignans, obtained by biomimetic oxidative dimerization of caffeic or ferulic acid methyl ester followed by derivatization reactions, was tested for its antiangiogenic activity in the CAM (chorioallantoic membrane) assay. The dimerization product of caffeic acid methyl ester (2a) (methyl (E)-3-[2-(3,4-dihydroxyphenyl)-7-hydroxy-3-methoxycarbonyl-2,3-dihydro-1-benzofuran-5-yl]prop-2-enoate) showed a pronounced antiangiogenic activity, especially the 2R,3R-enantiomer. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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