| Autor: |
Kovalenko LP; Laboratory of Drug Toxicology, Institute of Pharmacology, Russian Academy of Medical Sciences, Baltiiskaya ul. 8, Moscow, 125315 Russia., Smol'nikova NM, Alekseeva SV, Nemova EP, Sorokina AV, Miramedova MG, Kurapova SP, Sidorina EI, Kulakova AV, Daugel'-Dauge NO |
| Jazyk: |
ruština |
| Zdroj: |
Eksperimental'naia i klinicheskaia farmakologiia [Eksp Klin Farmakol] 2002 Jan-Feb; Vol. 65 (1), pp. 62-4. |
| Abstrakt: |
Within the framework of a preclinical investigation, the new nootrope drug noopept (N-phenyl-acetyl-L-propyl-glycine ethylate) was tested for chronic toxicity upon peroral administration in a dose of 10 or 100 mg/kg over 6 months in both male and female rabbits. The results of observations showed that noopept administered in this dose range induced no irreversible pathologic changes in the organs and systems studied and exhibited no allergenic, immunotoxic, and mutagen activity. The drug affected neither the generative function nor the antenatal or postnatal progeny development. Noopept produced a dose-dependent suppression of inflammation reaction to concanavalin A and stimulated the cellular and humoral immune response in mice. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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