| Autor: |
Creusot RJ; Windeyer Institute of Medical Science, University College London, 46 Cleveland Street, W1T 4JF, UK., Mitchison NA, Terazzini NM |
| Jazyk: |
angličtina |
| Zdroj: |
Molecular immunology [Mol Immunol] 2002 May; Vol. 38 (12-13), pp. 997-1002. |
| DOI: |
10.1016/s0161-5890(02)00028-7 |
| Abstrakt: |
The immunological synapse plays a central role in organising the immune system. Through their synaptic activity both T and B cells usually, but not always, acquire the information that critically determines the level and nature of the responses that they make. For T cells much of that information comes from epicrine and paracrine cell-cell interactions in the cluster that forms around a dendritic cell. These interactions are being dissected by experiments in which two populations of TCR-transgenic T cells are combined in vivo. Another important aspect of synaptic activity is the way in which different levels of expression of MHC class II molecules influence Th1/Th2 balance. In exploring this form of control we are learning something of general importance about cis-regulation. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
|
Full Text from ScienceDirect