TSH secretory pattern and thyroid function in children with growth hormone neurosecretory dysfunction.

Autor: Quevedo MF; Department of Pediatrics, University of Maryland School of Medicine, Baltimore, USA., Pironis B, Palese T, Counts DR, De Luca F
Jazyk: angličtina
Zdroj: Journal of pediatric endocrinology & metabolism : JPEM [J Pediatr Endocrinol Metab] 2002 Apr; Vol. 15 (4), pp. 377-80.
DOI: 10.1515/jpem.2002.15.4.377
Abstrakt: We evaluated the TSH secretory pattern and free T4 in 10 prepubertal children with short stature, normal response to GH provocative tests, and reduced GH integrated concentration (IC-GH) (GH neurosecretory dysfunction). Although their nadir TSH, peak TSH, TSH surge, and free T4 were lower than those of 12 children with short stature and normal IC-GH, none of the differences reached statistical significance. Thus, our results suggest that children with low IC-GH (GH neurosecretory dysfunction) exhibit a TSH secretory pattern and thyroid function similar to those with normal IC-GH.
Databáze: MEDLINE