| Autor: |
Salem OI; 8.5 Pharmaceutical and Medicinal Chemistry, Saarland University, P.O.Box 15 11 50, D-66041 Saarbrücken, Germany., Schulz T, Hartmann RW |
| Jazyk: |
angličtina |
| Zdroj: |
Archiv der Pharmazie [Arch Pharm (Weinheim)] 2002 May; Vol. 335 (2), pp. 83-88. |
| DOI: |
10.1002/1521-4184(200205)335:2<83::AID-ARDP83>3.0.CO;2-1 |
| Abstrakt: |
The synthesis and biological evaluation of 4-(4-(alkyl- and phenylaminocarbonyl)-benzoyl)benzoic acids (4a-4d) as non-steroidal inhibitors of steroid 5alpha-reductase are described. The compounds were tested in vitro for inhibitory activity toward rat and human 5alpha-reductase isozymes 1 and 2 at a concentration of 10 &mgr;M.The most active inhibitor for the human type 2 isozyme was 4-(4-(phenylaminocarbonyl)benzoyl) benzoic acid, compound 4c (IC (50) = 0.82 &mgr;M). |
| Databáze: |
MEDLINE |
| Externí odkaz: |
|
Plný text