[Synthetic peptides -- analogs of biologically active fragment of the differentiation factor from HL-60 cells show radioprotective and adaptogenic activities].

Autor: Goncharenko EN; Lomonosov Moskow State University, 119899 Russia., Deev LI, Kostanian IA, Astapova MV, Akhalaia MIa, Kudriashova NIu, Surina EA
Jazyk: ruština
Zdroj: Radiatsionnaia biologiia, radioecologiia [Radiats Biol Radioecol] 2002 Mar-Apr; Vol. 42 (2), pp. 164-8.
Abstrakt: It was shown that the addition of synthetic six-membered peptide (HLDF-6) and its Tyr-analog (HLDF-Y) to cultural medium significantly increased the survival of cells HL-60, treated by cold shock. The prophylactic administration of HDLF-Y (1 mg/kg, 4 hours prior to applied actions) decreased the response of hypothalamushypophysis-adrenal glands system and sympathicoadrenal system of rat males on supercooling and also increased the resistance of mouse males to supercooling and X-irradiation. In the experiences with females HDLF-Y did not show the similar biological activity.
Databáze: MEDLINE