Enantioselective desymmetrization of meso bicyclic hydrazines: a novel approach to the asymmetric synthesis of polysubstituted amino cyclopentanic cores.

Autor: Pérez Luna A; Laboratoire de Chimie Thèrapeutique UMR 8638 associée au CNRS et à l'Université René Descartes Faculté des Sciences Pharmaceutiques et Biologiques, Paris, France., Ceschi MA, Bonin M, Micouin L, Husson HP, Gougeon S, Estenne-Bouhtou G, Marabout B, Sevrin M, George P
Jazyk: angličtina
Zdroj: The Journal of organic chemistry [J Org Chem] 2002 May 17; Vol. 67 (10), pp. 3522-4.
DOI: 10.1021/jo011190e
Abstrakt: Catalytic asymmetric hydroboration can be successfully applied to meso bicyclic hydrazines. The resulting alcohols are of great synthetic interest and can lead in a straightforward manner to cyclopentanic diamino alcohols with good enantiomeric purity.
Databáze: MEDLINE