[Evaluation of expression and correlation between P53, BCL-2 and BAX proteins in ovarian neoplasms].

Autor:	Bar JK; Katedry i Zakładu Immunologii Klinicznej Akademii Medycznej we Wrocławiu., Sobańska E, Popiela A, Goluda M
Jazyk:	polština
Zdroj:	Ginekologia polska [Ginekol Pol] 2002 Feb; Vol. 73 (2), pp. 102-9.
Abstrakt:	Objectives: Interactions between BCL-2 and other proteins regulating programmed cells death in ovarian carcinomas are poorly understood. Design: The evaluation of expression of P53, BCL-2 and BAX proteins in ovarian carcinomas. The associations between oncoproteins studied and the histological structure, grade of differentiation and stage of disease were also analysed. Material and Methods: The expression of P53, BCL-2 and BAX was evaluated by immunoperoxidase technique (PAP) in tissue sections and corresponding cyst and/or ascitic fluid cells in individual patients with ovarian carcinoma. Results: It was shown that the expression of P53 and BAX was comparable in tissue sections and cyst or ascitic fluid cells of individual patients, however the presence of BCL-2 was detected more frequently in tissue sections. No correlations between markers studied and histological subtypes and grade of carcinoma were found. Taking into account the relationship between P53, BCL-2 and BAX expression, it was possible to classify the studied ovarian carcinomas into four phenotypes. Ovarian cancers with phenotype P53+/BCL-2- were more frequent in III/IV degree FIGO stages whereas the phenotype P53-/BCL-2+ were identified mainly in patients in I/II degree FIGO stages. The progression of disease and death occurred more frequently in groups with phenotype P53+/BCL-2+ and P53-/BCL-2-. Conclusions: Our observations indicated that estimation of P53, BCL-2 and BAX protein expression may be important in the choice of the chemotherapy.
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu