| Autor: |
Morzycki JW; University of Bialystok, Institute of Chemistry, al. Pilsudskiego 11/4, Poland. morzycki@noc.uwb.edu.pl, Wawer I, Gryszkiewicz A, Maj J, Siergiejczyk L, Zaworska A |
| Jazyk: |
angličtina |
| Zdroj: |
Steroids [Steroids] 2002 Jun; Vol. 67 (7), pp. 621-6. |
| DOI: |
10.1016/s0039-128x(02)00012-0 |
| Abstrakt: |
A group of biologically active 4-azasteroids was studied by 13C-NMR spectroscopy in solution and in the solid phase. A full assignment of signals in the spectra of samples in chloroform was performed for thirteen 4-azasteroids using two-dimensional techniques. Substituent and steric effects of a nitrogen atom, and their influence on chemical shifts of the neighboring carbon atoms are discussed. CP MAS spectra were obtained for five 4-azasteroids including finasteride. The spectra confirmed polymorphism of the latter compound. In addition to the polymorphic forms that are already known, a new molecular complex of finasteride with dioxane is reported. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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