| Autor: |
Dees C; Photongen, Inc., Knoxville, TN 37931, USA., Harkins J, Petersen MG, Fisher WG, Wachter EA |
| Jazyk: |
angličtina |
| Zdroj: |
Photochemistry and photobiology [Photochem Photobiol] 2002 Mar; Vol. 75 (3), pp. 296-301. |
| DOI: |
10.1562/0031-8655(2002)075<0296:tomcmw>2.0.co;2 |
| Abstrakt: |
Treatment of cutaneous melanoma (M-3 and B16-F10 implanted in mice) with rapidly-scanned, tightly-focused near infrared light elicits selective destruction of tumor tissue. A single laser treatment yielded complete eradication in >90% of B16-F10 tumors with thicknesses of approximately 3 mm; amelanotic M-3 tumors proved less responsive (ca 25% clearance rate). In addition to local tumor destruction, laser treatment of B16-F10 tumors in immunocompetent mice stimulated enhanced cytokine levels (interleukin-2 and interleukin-10) within treated tumor tissues and rejection of tumor cells upon a subsequent challenge dose. Such an antitumor immune response may lead to improved outcomes at both the treatment site and at sites of distant metastasis. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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