| Autor: |
Stern RA; Department of Psychiatry and Human Behavior, Brown University School of Medicine, Providence, Rhode Island, USA., Steketee MC, Durr AL, Prange AJ, Golden RN |
| Jazyk: |
angličtina |
| Zdroj: |
Convulsive therapy [Convuls Ther] 1993; Vol. 9 (4), pp. 285-292. |
| Abstrakt: |
Neurocognitive deficits, including acute confusion and memory impairment, remain important effects of electroconvulsive therapy (ECT). Laboratory and clinical research demonstrates interactions among neurocognitive functioning, the hypothalmic-pituitary-thyroid axis, depressive mood, and ECT. Preclinical studies have demonstrated that exogenous triiodothyronine (T(3)) administered to animals receiving electroconvulsive shock (ECS) protects against ECS-related amnesia and accelerates the "antidepressant effects" of ECS, possibly due to alterations in catecholamine and/or indoleamine neurotransmission. Clinical data suggest that combined treatment with T(3) and ECT results in increased clinical efficacy of ECT and diminished neurocognitive side effects. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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