[Effects of T-type calcium channel blockers on spontaneous meiotic maturation of mouse ovarian oocytes in vitro].

Autor: Hotsuliak IaM; A.A. Bogomoletz Institute of Physiology, National Academy of Science of Ukraine, Kiev., Berdyieva TK, Libert SV
Jazyk: ukrajinština
Zdroj: Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994) [Fiziol Zh (1994)] 2002; Vol. 48 (1), pp. 98-101.
Abstrakt: We studied the effects of blockers of the T-type Ca2+ channels on resumption of meiosis and spontaneous meiotic maturation of murine ovarial oocytes in vitro. We found that the efficiency of suppression of oocyte maturation by blockers of the Ca2+ channels increases in the following succession: amiloride hydrochloride, mebifradil, NiCl2. It is supposed that there is a possibility to use blockers of the T-type Ca2+ channels for creation of new combined intrauterine contraceptives.
Databáze: MEDLINE