| Autor: |
Sangha S; Ochsner Cardiomyopathy and Heart Transplantation Center, Ochsner Clinic Foundation, New Orleans, LA 70121, USA., Uber PA, Mehra MR |
| Jazyk: |
angličtina |
| Zdroj: |
Congestive heart failure (Greenwich, Conn.) [Congest Heart Fail] 2002 Mar-Apr; Vol. 8 (2), pp. 93-6. |
| DOI: |
10.1111/j.1527-5299.2002.00759.x |
| Abstrakt: |
Careful thought must be given to the development of bystander pathology that could mimic worsening of heart failure. Recent trials with patients receiving amiodarone record a low rate of amiodarone pulmonary toxicity of 1.6%. Bronchoalveolar lavage in amiodarone toxicity demonstrates an absolute and relative lymphocytic alveolitis, suggesting hypersensitivity, but this finding is neither sensitive nor specific. Recently, KL-6, a mucin-like high molecular weight glycoprotein secreted by proliferating type II alveolar pneumocytes, has been identified as a potential marker of interstitial pneumonitis. A high index of suspicion combined with rapid exclusion of common confounding mimics can help in establishing the diagnosis of amiodarone lung toxicity. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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