| Autor: |
Wubbels RJ; Vestibular Department ENT, Academic Medical Center, University of Amsterdam, P.O.Box 22660, 1100 DD Amsterdam, The Netherlands. r.j.wubbels@amc.uva.nl, Sondag HN, van Marle J, de Jong HA |
| Jazyk: |
angličtina |
| Zdroj: |
Brain research bulletin [Brain Res Bull] 2002 Mar 15; Vol. 57 (5), pp. 677-82. |
| DOI: |
10.1016/s0361-9230(01)00778-x |
| Abstrakt: |
The effect of prolonged exposure to hypergravity on the morphology of vestibular epithelia of rats was investigated. At the age of 1 month, i.e., when vestibular end organs are fully maturated, three rats were transferred to a hypergravity environment of 2.5 g inside a large radius centrifuge. After 9 months, vestibular epithelia of these animals and of three control animals were immunohistochemically labeled for actin and tubulin. The apical cross-sectional area of epithelial cells of hypergravity exposed rats appeared to be smaller in all end organs. Area reduction was 1.9% in the saccule (not significant), 5.0% in the utricle (p < 0.005), and 11.6% in the crista (p<<0.001). No indications for a deterioration of vestibular functioning were observed. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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