Retinoids enhance cisplatin-based chemoradiation in cervical cancer cells in vitro.

Autor: Scribner DR Jr; Department of Obstetrics and Gynecology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73190, USA., Benbrook DM
Jazyk: angličtina
Zdroj: Gynecologic oncology [Gynecol Oncol] 2002 Apr; Vol. 85 (1), pp. 223-5.
DOI: 10.1006/gyno.2002.6590
Abstrakt: Objective: The aim of this study was to determine whether receptor-dependent and receptor-independent retinoids sensitize cervical cancer cells to clinically relevant doses of concurrent radiation and cisplatin.
Methods: The clonogenic assay was performed on SiHa cervical carcinoma cultures treated with 5 microM 9-cis-retinoic acid (RA) or 3 microM 4-HPR for 3 days prior to and following concurrent treatment with 3 microM cisplatin and 2 Gy of Co(60) radiation.
Results: Neither 9-cis-RA nor 4-HPR significantly decreased survival for radiation only or cisplatin only (t test: P < 0.05), but both significantly decreased survival of cultures receiving concurrent chemoradiation (t test: 9-cis-RA P = 0.045; 4-HPR P = 0.027).
Conclusions: Both receptor-dependent and receptor-independent retinoids enhance concurrent chemoradiation effects in vitro.
Databáze: MEDLINE
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