| Autor: |
Cine N; Department of Genetics, Institute for Experimental Medical Research, University of Ystanbul, Turkey., Hatemi AC, Erginel-Unaltuna N |
| Jazyk: |
angličtina |
| Zdroj: |
Clinical genetics [Clin Genet] 2002 Jan; Vol. 61 (1), pp. 66-70. |
| DOI: |
10.1034/j.1399-0004.2002.610113.x |
| Abstrakt: |
In this study we examined a possible association between a 27 base pair (bp)-repeat polymorphism in intron 4 of the ecNOS gene and myocardial infarction (MI) in a subgroup of the Turkish population. We compared MI and control groups for the frequencies of the ecNOS alleles and their genotypes. The frequency of the ecNOS 4a/a and 4a/b genotypes was found to be significantly higher in the MI group than in the control group. Interestingly, the frequency of the ecNOS 4a/b polymorphism was found to be significantly higher in the selected MI group (patients with no known secondary risk factors) than in the control and non-selected MI group. We found that the patients with MI had the frequency of the a/a genotype 4.3%, of the a/b genotype 26.6% and the b/b genotype 69.1%. The controls, however, showed only 0.6% for a/a, 18.0% for a/b and 81.4% for the b/b genotype (P < 0.001; chi2 = 13.626). In this study, we show that myocardial infarction is associated with one subtype of ecNOS gene polymorphism. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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