[HindIII DNA-polymorphism of lipoprotein lipase gene in elderly patients with ischemic heart disease].
| Autor: | Malygina NA, Kostomarova IV, Deriagin GV, Serova LD |
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| Jazyk: | ruština |
| Zdroj: | Terapevticheskii arkhiv [Ter Arkh] 2002; Vol. 74 (2), pp. 64-6. |
| Abstrakt: | Aim: To determine incidence of HindIII alleles of lipoprotein lipase (LPL) in Russian elderly patients with stable effort angina (SEA) functional class II-III regarding lipid metabolism. Material and Methods: Genotyping by LPL gene was performed in 103 patients with SEA. Of them 13 patients survived myocardial infarction (MI), 29 patients had diabetes mellitus. Results: Incidence of alleles of HindIII DNA-polymorphism of LPL gene both in healthy and IHD patients is comparable with that in the West European populations. Conclusion: Genotype H+H+ of LPL gene is one of the markers of predisposition to MI, while allele H- is one of the resistance marks. |
| Databáze: | MEDLINE |
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