Plasma adenosine concentration increases during exercise: a possible contributing factor in exercise-induced bronchoconstriction in asthma.

Autor: Vizi E; Department of Pathophysiology, National Korányi Institute for Tuberculosis and Pulmonology, Budapest, Hungary., Huszár E, Csoma Z, Böszörményi-Nagy G, Barát E, Horváth I, Herjavecz I, Kollai M
Jazyk: angličtina
Zdroj: The Journal of allergy and clinical immunology [J Allergy Clin Immunol] 2002 Mar; Vol. 109 (3), pp. 446-8.
DOI: 10.1067/mai.2002.121955
Abstrakt: We investigated whether the level of plasma adenosine (ADO) changed during exercise and whether this could be related to exercise-induced bronchoconstriction. Baseline levels of ADO did not differ, but exercise resulted in higher ADO in patients with asthma than in healthy subjects (86 +/- 35 vs 59 +/- 16 nmol/L; P <.001). In patients with asthma, the increase in ADO was related to decreases in FEV(1) (r (2) = 0.475; P <.05) and SaO(2) (r (2) = 0.693; P <.05). These data suggest that adenosine might be involved in the development of exercise-induced bronchoconstriction.
Databáze: MEDLINE
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