[Comparative study of the fate of fluorofur and 5-fluorouracil in the organism].

Autor: Giller SA, Meĭren DV, Khagi KhB, Koptelova MN, Shafro EA
Jazyk: ruština
Zdroj: Voprosy onkologii [Vopr Onkol] 1975; Vol. 21 (9), pp. 84-8.
Abstrakt: Fluorofur (FT) is slowly splitted in tissues releasing free 5-FU. The duration of stay in the organism of 5-FU formed from FT is longer than that of 5-FU administered solely. Moreover, FT does not result in the formation of such high 5-FU concentrations, as observed while using 5-FU itself. It seems to account for an insignificant toxicity of FT and its greater efficacy in treatment of malignant tumors.
Databáze: MEDLINE