| Autor: |
Fel'dblium IV; State Medical Academy, Perm, Russia., Vorob'eva NN, Nikolaeva AM, Borisova VN, Mel'nikov VA, Budanov MV, Iakovleva IA, Kaz'ianin AV, Pushkareva EV, Griaznov VN, Griaznova DV, Shalunova NV, Perelygina OV, Ozeretskovskiĭ NA, Bektimirov TA |
| Jazyk: |
ruština |
| Zdroj: |
Zhurnal mikrobiologii, epidemiologii i immunobiologii [Zh Mikrobiol Epidemiol Immunobiol] 2001 Nov-Dec (6), pp. 50-2. |
| Abstrakt: |
Bubo-M, the first Russian combined vaccine, was found to have low reactogenicity. The difference between the number of postvaccinal reactions in the group of children immunized with Bubo-M (25.9%) and those in the group of children who had been simultaneously injected into different sites of the body with ADS-M toxoid (adsorbed DT toxoid with reduced antigen content) and hepatitis B vaccine (26.7%) was not statistically significant. Following immunization a considerable increase in the level of diphtheria and tetanus antibodies (p < 0.005) was observed in all children (100%), the level of HBs antibodies in the group of children immunized with Bubo-M (the geometric mean titer: 13,721 IU/l) essentially exceeding that observed in the control group injected with ADS-M toxoid and hepatitis B vaccine (the geometric mean of the titer: 2,441 IU/l). Bubo-M was duly registered and allowed for industrial production and medical use. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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