| Autor: |
Baidoshvili A; Department of Pathology, Vrije Universiteit Medical Center ICAR-VU, 1081 HV Amsterdam, The Netherlands., Nijmeijer R, Lagrand WK, Hack CE, Niessen HW |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of clinical pathology [J Clin Pathol] 2002 Feb; Vol. 55 (2), pp. 152-3. |
| DOI: |
10.1136/jcp.55.2.152 |
| Abstrakt: |
This report hypothesises an active role for the acute phase protein, C reactive protein (CRP), in local inflammatory reactions. This was studied in infarction sites from liver and kidney in a patient who died as a result of multiple complications after cholecystectomy. In this patient, a general acute phase protein reaction was induced, with an increase in plasma CRP. In infarction sites of kidney and liver, colocalisation of CRP and activated complement were found, whereas non-infarct sites were negative for CRP and complement. These results suggest that CRP directly participates in local inflammatory processes, possibly via complement activation, after binding of a suitable ligand. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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