| Autor: |
Seo Y; Department of Chemistry, M/C 0212, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061, USA., Hoch J, Abdel-Kader M, Malone S, Derveld I, Adams H, Werkhoven MC, Wisse JH, Mamber SW, Dalton JM, Kingston DG |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of natural products [J Nat Prod] 2002 Feb; Vol. 65 (2), pp. 170-4. |
| DOI: |
10.1021/np0103620 |
| Abstrakt: |
Bioassay-guided fractionation of the MeOH extract of Acacia tenuifolia using the engineered yeast strains 1138, 1140, 1353, and Sc7 as the bioassay tool resulted in the isolation of the three new saponins 3, 5, and 6 and the three known saponins 1, 2, and 4. The structures of the new compounds were established on the basis of HRMS, 1D and 2D NMR spectral data on the intact saponins, and GC-MS analyses of the sugars. Compounds 1,2 and 5,6 showed cytotoxicity against mammalian cell lines. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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