| Autor: |
Oyama Y; Division of Immune Therapy and Autoimmune Disease, Northwestern University School of Medicine, Chicago, IL 60611, USA., Cohen B, Traynor A, Brush M, Rodriguez J, Burt RK |
| Jazyk: |
angličtina |
| Zdroj: |
Bone marrow transplantation [Bone Marrow Transplant] 2002 Jan; Vol. 29 (1), pp. 81-5. |
| DOI: |
10.1038/sj.bmt.1703324 |
| Abstrakt: |
Autologous hematopoietic stem cell transplantation (HSCT) is currently being evaluated as a therapy for patients with progressive multiple sclerosis (MS) at risk of debilitating neurological impairment. While preliminary results from a few studies have been reported, little is known about toxicities or outcome of HSCT for MS. We report a relatively frequent triad of non-infectious fever, rash and fatigue or lassitude that may also be associated with pruritus, pulmonary symptoms, and eosinophilia and frequently occurs around engraftment. This syndrome occurred in 26% of our series of patients (5/19) undergoing HSCT for multiple sclerosis. The engraftment syndrome is usually self-limited but may require intervention with systemic corticosteroids. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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